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Introducing Biofunctional groups on the surface of carbon nanotube to make an efficient biocompatible vector
Paper ID : 2211-UFGNSM13-FULL (R2)
Authors:
Abstract:
Carbon nanotubes have attracted great interdisciplinary interest because of their unique structure and properties. However, carbon-nanotube research in biological system is challenge by several problems such as insolubility and cytotoxicity. However, in order to improve solubility in physiological solutions, reducing cytotoxicity, and selective binding affinity to biotargets, these carbon nanomaterial need to be surface functionalized with biocompatible groups. Using appropriate chemistry, a variety of biologically active molecules can be covalently attached to carbon nanostructures. These functionalized derivatives can be used for design of vaccine, drug, gene delivery systems and as scaffolds for tissue and bone engineering. Therefore, applying appropriate biomolecule for covalent functionalization of carbon nanomaterials has become an important area of research both from fundamental and application standpoints. This research has used arginine amino acid as a functional group. According to its bulk and charged side chain, arginine may be a proper biomoleclue for CNT functionalization. To make this process CNTs should be first activated by acidic oxidation to introduce carboxyl groups on them. Then functionalization process is carried out by adding arginine to oxidized-CNT in basic environment. Carboxyl groups production in Oxidized-CNT and amide bond formation in Functionalizad-CNT (f-CNT) is demonstrated by FT-IR. The dispersibility of f-CNT is checked that approved increasing solubility of f-CNT in water. This nano-biocomplex will be used as an efficient biocompatible vector to transfer siRNA to Cancer cell lines in near future by our research center.
Keywords:
Carbon nanotube, Functionalization, Arginine, Biocompatibility
Status : Paper Accepted (Poster Presentation)