| Chitosan and Poly (ethylene glycol) Coated Magnetic Iron Oxide Nanoparticles as a New Smart Drug Carrier for Controlled Drug Release |
| Paper ID : 2277-UFGNSM13-FULL |
| Authors: |
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Alireza Kavand, Ali yasbolaghi Polymer Chemistry Department, School of Science, University of Tehran |
| Abstract: |
| With the rapid development of nanotechnology, magnetic iron oxide (Fe3O4) nanoparticles have shown great potential applications in many biological and medicinal fields [1] such as magnetically guided site-specific drug delivery agents [2]. These materials require sophisticated coatings, such as poly(ethylene glycol) and chitosan. Chitosan coating has been used mostly because is a biodegradable natural polymer with a great potential for pharmaceutical applications [3]. Poly(ethylene glycol) is of great interest, especially in biological applications [4]. In this work, we prepared nanoparticles were coated with a star PEG with carboxylic end groups than modified nanoparticles were coated with chitosan as natural materials. Magnetite nanoparticles were prepared by co-precipitation method [5]. The HO-PEG-(COOH)3 was acrylated and Micheal reaction was carried out between acrylated PEG-(COOH)3 and 3-aminopropyl triethoxysilane (APTES) as a coupling agent. In the next step, iron oxide nanoparticle was coupled with the above-mentioned adduct. Then, the modified magnetite nanoparticles were coated with chitosan. Chitosan contains amino groups (–NH2) and poly(ethylene glycol) contains carboxylic groups (–COOH), therefore chitosan attached to the surface of modified nanoparticles. The size of the particles and the chemical nature of the coating were determined by SEM and FTIR, respectively. Magnetite nanoparticles with average particle size of > 20 nm were prepared. We describe a magnetic nanoparticle drug carrier for controlled drug release that responds to the change in external pH. |
| Keywords: |
| Magnetic iron oxide nanoparticles, Chitosan, Poly(ethylene glycol), Drug delivery, Nanocarrier |
| Status : Paper Accepted (Poster Presentation) |
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