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Water Soluble formulations of Ibuprofen by Nano- and micro-particulate Formation Using ESD Technique
Paper ID : 2374-UFGNSM13-FULL (R1)
Authors:
Abstract:
Many poorly water-soluble drugs have been used for curing diseases, have low bioavailability in body that causes using high dosage of them. Polymers coating for enhancing solubility related to their polymeric structure can be used for enhancing solubility of these drugs. Ibuprofen and Naproxen are among of these drugs. In this work was Ibuprofen used. A novel technique for the production of nano- and micro-particulate formulations of Ibuprofen as a poorly water-soluble drug has been developed by emulsion solvent diffusion technique. This technique involves mixing of two liquid solutions, an aqueous phase and an organic phase, respectively. The amount of organic–aqueous phases have been investigated which play significant role in the reduction of particle size and solubility of the drug. The purpose of this study was to develop a technique to enhance the dissolution rate of poorly water-soluble drugs with hydroxy propyl methyl cellulose with ESD technique. The pure Ibuprofen and the prepared agglomerates were characterized in terms of production yield, drug content, solubility, in vitro release profile, X-ray diffraction, fourier transforms infrared spectroscopy, ultraviolet-visible spectroscopy and scanning electron microscopy.
Keywords:
Poorly water soluble drug; Hydroxypropyl Methylcellulose; Emulsion Solvent Diffusion; Microparticles; Nanoparticles
Status : Paper Accepted (Poster Presentation)